Actor Hugh Jackman has thanked fans while Ryan Reynolds admitted it's "kind of hard to process" after Deadpool & Wolverine made a whopping $US438 million ($A668 million) globally during its opening weekend.
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The R-rated Marvel blockbuster is now the eighth-biggest opening movie of all time in the US after making $US220 million ($A336 million) in North America alone.
Australia's Jackman (Wolverine), 55, took to social media to express his gratitude to fans: "Deadpool and Wolverine is the #1 movie in the world. Thank you ALL."
Co-star Reynolds, 47, reacted on his Instagram story.
"This is kind of hard to process," he wrote.
"But thank you to everyone who went to see the film this weekend ... wow."
Reynolds recently divulged that he changed the film's title because Internet leakers "hated" the Shawn Levy flick's original name.
He chose to change the name in February after online sleuths went ballistic after learning the film was called Deadpool and Friend.
Reynolds explained the switch during an appearance on Jimmy Kimmel Live! in which the movie's stars filled in as guest co-hosts.
"The title leaked. We looked at it and listened, and they hated that title. We were not feeling so good about that anymore," he said.
Although he was adamant to amend the film's name, Reynolds admitted it took a while to convince Marvel Studios to agree to the change.
"We were like, 'No, we're changing the title, I will never call this movie Deadpool and Friend. And they did it, they did it. They really changed the title."
Even before the name leaked, Reynolds was determined to ensure more sensitive details about the movie didn't make their way online before hitting cinemas, and so planned to film a fake "intentionally bad" film known as Alpha Cop to throw leakers off the scent.
"I even had one of the posters made - it was about two guys who are sharing one brain and together they make the ultimate cop.
"And the poster says, 'Alpha Cop: Two Cops, One Brain. All Balls'," Reynolds explained to Jackman during a stint on US YouTube talk show Hot Ones.
"It was meant to be kind of like horrible, so 10 people in America would go see this movie on opening weekend and five minutes into the movie, the Marvel logo would flip up and it would actually be Deadpool & Wolverine."
Australian Associated Press
